Hericium Erinaceus Mycelium Exerts Neuroprotective Effect in Parkinson’s Disease-in Vitro and in vivo Models
Hericium Erinaceus (H.E.) is a well-known edible and folk medicinal fungi in Japan, China, and other Asian countries without harmful effects. It has been recognized that this unique mushroom is capable of keeping the brain healthy, supporting the immune system to help prevent gastric cancer and other diseases, boosting mood and concentration, decreasing inflammatory processes in the body. But more scientific researchers are needed to confirm its nutritional and medicinal effects. In the present study, we investigated the effects of Hericium Erinaceus mycelium (H.E. mycelium) against 1-methyl-4-phenylpyridinium(MPP+)-induced neurotoxicity in PC12 cells and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinsonian mice. In the cell viability results, treatment with H.E.mycelium increased the cell viability in MPP+-treated cells and induced antioxidant activity in PC12 cells. H.E. mycelium also reduced MPTP-induced loss of dopamine concentration level and tyrosine hydroxylase (TH) positive cells in mice. Our results suggest that H.E.mycelium performs significant protection of dopaminergic neuron under severe conditions and is very effective in the treatment of damaged neuron in the brain to recover in the case of Parkinson’s disease.